The causal relationships between inflammatory cytokines, blood metabolites, and thyroid cancer: a two-step Mendelian randomization analysis
DOI:
https://doi.org/10.1348/36cymn21Keywords:
Thyroid , , cancer , malignant tumor, Tumor microen-vironmentAbstract
Background Thyroid cancer is a prevalent malignant tumor, especially with a higher incidence in women. Tumor microen-vironment changes induced by inflammation and alterations in metabolic characteristics are critical in the development of thyroid cancer. Nevertheless, their causal relationships remain unclear.
Methods We utilized thyroid cancer GWAS data from the Global Biobank Meta-Analysis Initiative and GWAS data of 91inflammatory cytokines and 1400 blood metabolites obtained from the GWAS Catalog to evaluate the causality between inflammatory cytokines, blood metabolites, and thyroid cancer using Mendelian randomization (MR). Initially, we identi-fied inflammatory cytokines having a significant causal effect on thyroid cancer. Subsequently, for the identified positive blood metabolites, we applied a two-step mediation MR method to examine their mediating role in the causal effect of specific inflammatory cytokines on thyroid cancer.
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